MaxxiSAMe Is SAM-e Formula for Pets

Supports Liver Health & Cognitive Function

MaxxiSAMe is MaxxiDog's own proprietary SAM-e formula for pets. MaxxiSAMe helps to protect and maintain good liver health in dogs & cats and supports cognitive function in aging pets.

MaxxiSAMe liver brain

What Is SAM-e?

How Does SAM-e Support Liver Health in Dogs & Cats?

How SAM-e Supports Cognitive Function in Aging Pets

Bonus Benefits of SAM-e

What Makes MaxxiSAMe Different

The Benefits of SAM-e Powder over Coated Tablets

How Best To Administer MaxxiSAMe

Potential Side Effects of SAM-e

Where to Buy MaxxiSAMe

Where to Buy MaxxiSAMe?

MaxxiSAMe is available in the USA on Chewy and maxxipaws or click the logos below.



What Is SAM-e?

SAM-e is a compound that is made naturally in the body and plays an important role in normal bodily function. The full name is S-adenosylmethionine but it is commonly referred to as SAM-e or SAMe.

SAM-e is formed from the essential amino acid methionine and adenosine triphosphate and is found in every living cell in the body. SAM-e, as it is within the cell, is the body's most important antioxidant but antioxidants are chemicals (natural and manmade) that can prevent or slow down cell damage.

There are no food sources of SAM-e but it can be given as a supplement. SAM-e has been used as human dietary supplement since 1999 in the US and for longer in many countries in Europe.

SAM-e is used to treat various conditions in humans, e.g. depression, anxiety, osteoarthritis, fibromyalgia, chronic fatigue syndrome (CFS), lower back pain, tendonitis, liver disease, dementia, and to slow down the aging progress.

"A sufficient number of clinical trials have supported the use of SAMe in disorders including depression, dementia, vacuolar myelopathy, and liver disease. Further studies should be performed, and it is of primary importance that the safety and tolerability of SAMe be assured. Reviews of clinical studies to date indicate that SAMe has a low incidence of side effects with an excellent record of tolerability" (The American Journal of Clinical Nutrition)

In recent years, SAM-e has been used for pets as well, and then mainly as liver supplement for dogs and cats. However, as with humans SAM-e can benefit pets in more ways.

MaxxiSAMe is especially formulated by MaxxiDog to address two common health issues in our pets, i.e. liver and brain (cognitive function) health.


How SAM-e Supports Liver Health in Pets

The liver produces SAM-e from the amino acid methionine. It is converted into glutathione through a chemical process in the liver called transsulfuration. Glutathione plays an important role in protecting the liver cells (hepatocytes) from damage from the waste products that the liver removes from the blood stream.

When the liver is damaged, then less SAM-e, and thus less glutathione, is produced. This means even more liver cells become damaged, i.e. vicious cycle has started.

SAM-e synthesis is depressed in chronic liver disease. Pre-clinical studies indicate that this could exacerbate liver injury and so supplementation may be useful therapy (Journal of Hepatology).

MaxxiSAMe liver brain

This Study confirms that low liver glutathione concentration is also common in dogs and cats with naturally occurring liver disease (necroinflammatory liver disorders, extrahepatic bile duct occlusion, and feline hepatic lipidosis).

SAM-e has been shown to increase the glutathione levels in dogs and cats.

This Study’s Review concludes "there is strong pre-clinical evidence that SAMe has important physiological roles in health and that liver disease of various aetiologies may perturb these. Furthermore, it is apparent that hepatocellular SAMe concentration can influence diverse pathophysiological processes including tissue oxidative stress, mitochondrial function, hepatocellular apoptosis, and malignant transformation, not to mention the intriguing data suggesting that chronic viral hepatitis may modulate interferon sensitivity through SAMe. These data suggest that SAMe could offer substantial clinical benefits".

MaxxiSAMe, Diet, Liver, Report

More studies are needed but there is a general professional consensus that SAM-e supplementation can benefit liver health in both humans and pets.

SAM-e supplementation increases the glutathione level, which protects the liver from further damage. The increased glutathione level may also help with healing and repair of cells (cell regeneration).

Liver supplements for dogs containing SAM-e are recommended for pets with various forms of liver disease including:

- Hepatic lipidosis (fatty liver)

- Cirrhosis

- Leptospirosis

- Hepatic fibrosis

- Cholangiohepatitis

- Certain breed-specific liver diseases

Liver supplements for dogs and cats containing SAM-e can also help the liver to recover from toxicities from non-steroidal anti-inflammatories (NSAIDS) and acetominophen (Tylenol). SAM-e may also be useful for pets receiving long-term treatments for diseases such as epilepsy, i.e. anytime when the medication used is metabolized by the liver.

How SAM-e Supports Cognitive Function

Like humans, our pets can develop degenerative brain diseases, known as feline or canine cognitive dysfunction syndrome (CDS).

Cognitive Dysfunction is a physical problem, i.e. the result of age-related changes in the brain but dogs and cats brains age in similar way. While feline and canine dementia is not exactly the same as human Alzheimer disease, the symptoms are similar, i.e. confusion, memory loss and other symptoms of reduced mental function.

Unfortunately, cognitive dysfunction is incurable but early diagnosis and intervention can slow it down and improve the pets' quality of life.

SAM-e supplementation has been shown to be safe and effective way to stall or improve mental decline in aging pets. SAM-e helps increase dopamine function in the brain, stimulates brain function and works as an antioxidant.

Studies in people have shown that there is an age-related effect in the concentration of SAM-e in the cerebrospinal fluid (CSF) found in the brain and spine, i.e. it declines with age.MaxxiSAMe, Liver, Brain

While studies on rats showed that tissue levels of SAM-e are significantly decreased in older rats compared to younger rats. The decline in the SAM-e concentration was evident in most organs, including the brain (A Roundtable Discussion; Teodoro Bottiglieri).

As there are no food sources of SAM-e, supplementation is required to increase the amount of SAM-e in the body.

David Mischoulon, MD, PhD, Director of Research, Depression Clinical and Research Program, Massachusetts General Hospital, says:

"SAMe helps with the whole spectrum of depressive symptoms, including difficulties with cognition, memory, and concentration, as well as mood enhancement. SAMe has few adverse effects and is well tolerated. It is not hepatoxic and is, in fact, beneficial to the liver. In many ways, it is the ideal medication for an elderly person.

Not much clinical data on SAMe's effect on dementia exist. We know that SAMe deficiencies are associated with increases in compounds that are toxic to the brain. We know that SAMe administration in animals can reverse or attenuate some of the adverse effects" (A Roundtable Discussion; David Mischoulon)

More studies are needed but there is a general professional consensus that SAM-e supplementation can benefit cognitive function in both humans and pets.

5 Brain Boosting Activities For Dogs SM.jpg

Bonus Benefits of SAM-e

SAM-e is not only good for liver and brain health. SAM-e is an effective anti-inflammatory. Multiple clinical trials involving thousands of people have shown SAM-e to improve joint health and help with the symptoms of osteoarthritis (Arthritis Foundation).

MaxxiSAMe does not replace the need for dog joint supplements like MaxxiFlex Plus for pets with existing joint problems and arthritis. However, it provides valuable joint support to pets that require SAM-e supplementation.

What Makes MaxxiSAMe Different

MaxxiSAMe is MaxxiDog's proprietary SAM-e formula for pets, i.e. it is our own unique formula. The development aims were simple:

- To develop effective premium quality SAM-e formula suitable for both dogs and cats

- To effectively support feline and canine liver health and cognitive function

- To make SAM-e formula for pets that is easy to administer

- To make SAM-e formula that is suitable for pet of any size, i.e. one size fits all

We are proud to say that we achieved all our goals with MaxxiSAMe advanced SAM-e formula for pets.


Improved Stability

In its native form, SAM-e is labile (easily broken down) and degrades rapidly. SAM-e therefore has to be formulated in a way that protects it from the enzymes in the stomach.

The stomach acid in dogs and cats is lower than in humans but lower pH means higher acidity. Normal human pH is 1.5 – 3.5 on an empty stomach, pH 5 when it is full. While the pH in dogs and cats is between 1 and 2, or significantly more acid.

The SAM-e used in MaxxiSAMe is patented stabilized powdered form of SAM-e. This protects the SAM-e from interaction with environmental factors, as well as from the other ingredients used in the formulation and guarantees the availability of the active substance (SAM-e) when taken orally.

What's more, this protects the SAM-e in the stomach and ensures it makes it to the intestine where it is absorbed.

Not Just SAM-e

First, MaxxiSAMe does not only contain SAM-e. It contains additional ingredients for extra potency. These ingredients are specifically chosen as they also support good liver health and cognitive function in aging pets. B vitamins also support the body's absorption of SAM-e.


Artichoke is high in silymarin (silybin, silidianin and silicristin) and cynarin but various studies have shown these compounds to be beneficial for liver health. Artichoke stimulates the production of bile in the liver as well as the discharge of bile from the system. These two functions are very important to the liver’s well-being.

Choline Bitartrate

Choline is an essential micronutrient. It is vital for healthy liver function and normal brain development. Choline deficiency causes muscle damage and abnormal deposition of fat in the liver, which results in a condition called non-alcoholic fatty liver disease. Animal studies have also shown that Choline is essential for optimal brain development and influences cognitive function in later life.


Inositol is involved in the production and action of neurotransmitters (chemicals that transmit messages between nerve cells). Inositol has calming effect that is beneficial for aging pets. What's more, Choline and Inositol work together to build the cell membranes and act on fat metabolism by hastening removal or decreasing the deposit of fat in the liver.

B Vitamins

MaxxiSAMe contains various B Vitamins. All of the B Vitamins are essential for the liver to perform its multitude of metabolic functions. Supplementation with B Vitamins is normally recommended for pets with hepatobiliary diseases (the hepatobiliary system refers to the liver, gall bladder and bile ducts, and how they work together to make bile).

MaxxiSAMe contains the necessary Vitamins B so you don’t have to buy or administer them separately.

For more information about The Other Ingredients Used in MaxxiSAMe click the photo below.MaxxiSAMe-click-bottle.jpg

Guaranteed Quality Ingredients & Manufacturing

We never compromise on quality. MaxxiSAMe is manufactured in USA, in GMP and NASC (National Animal Supplement Council) certified manufacturing facility.

All the ingredients used in MaxxiSAMe are NON-GMO and of pharmaceutical human grade quality. MaxxiSAMe does not contain any artificial flavors, colors, preservatives, or binders.

Not only that… we guarantee that the stated ingredients are present in the product at the date of manufacturing.

Certificate of Analysis

We do not accept any manufacturing batch unless it conforms to all product specifications.

A Certificate of Analysis is a document issued by Quality Assurance that confirms that a regulated product meets its product specification. It contains the actual results obtained from testing performed as part of quality control of an individual batch of a product.

The photo shows MaxxiSAMe Certificate of Analysis for a specific manufacturing batch. It shows that MaxxiSAMe conforms to all product specifications (microbiological, chemical contamination and amount of each ingredient). It also confirms that all production and testing documentation have been reviewed and found to be in compliance with the Good Manufacturing Practices Regulations.

MaxxiSAMe - Lot 34448 - exp 2017-June.jpgIf you like to see the Certificate of Analysis for any specific batch, just Contact Us with the lot number and we will send you a copy.

Last But Not Least

MaxxiSAMe is powder…

The Benefits Of SAM-e Powder Over Coated Tablets

SAM-e powder formula has many benefits over coated SAM-e tablets:

Easier Administration


Most pet owners have been there, trying to get their pet to eat coated tablets. Most pets hate them so you either have to hide the tablet in a treat (and hope your clever pet will not manage to outsmart you and just eat the treat) or manually force it down your pets throats, which let's face it, no pet owner enjoys doing and definitely not on a daily basis.

Coated tablets must be given on empty stomach because of the high acidity level in our pets' stomach. This is to shield the tablet so it can make it to the intestine to be absorbed. But as we have already seen, the stabilized powder used in MaxxiSAMe protects the SAM-e in the stomach and ensures it makes it to the intestine where it is absorbed.With powder, you can simple mix it in with your pet's food. This is because MaxxiSAMe, unlike coated tablets, can be given with food.

Quicker Absorption

The fiber base used in MaxxiSAMe powder makes absorption quicker and maximizes the availability of all of the ingredients in the intestinal tract.

What's more, including B vitamins in the formula increases the effectiveness of MaxxiSAMe as it helps with the absorption of the SAM-e.

Maximized Results

It is recommended to divide the daily SAM-e dosage between two servings for maximum results, i.e. to maximize the absorption of all ingredients. This is another thing you cannot do with coated SAM-e tablets.

Coated tablets are sensitive to moisture and extreme heat and can therefore not be split or crumbled.

Accurate Dosage

Powder allows the pet owner to administer the exact dosage for pet of any size. MaxxiSAMe is one product that fits dogs of all sizes, as well as cats.

This also makes it easier to increase or decrease the dosage if needed at the recommendation of your veterinarian.

Do you remember our goals with developing MaxxiSAMe? Did we achieve them? Yes, we sure did:

- To develop effective premium quality SAM-e formula for dogs and cats  check-symbol-red.png

- To effectively support feline and canine liver health and cognitive function  check-symbol-red.png

- To make SAM-e formula for pets that is easy to administer  check-symbol-red.png

- To make SAM-e formula that is suitable for any size of pet, i.e. one size fits all  check-symbol-red.png

How Best To Administer MaxxiSAMe

One of the great benefits of MaxxiSAMe is that it can be given with food (unlike coated tablets that must be given on empty stomach).

MaxxiSAMe, Liver, Brain

The easiest way to administer MaxxiSAMe is therefore to mix it in with your pet's food. For maximum results, it is recommended to divide the daily dosage between two servings.

MaxxiSAMe does not contain any artificial flavors, colors, preservatives, or binders, so it has natural flavor. The taste is mild (little sweet) to us humans and vast majority of pets happily eat their food when MaxxiSAMe has been added to it.

Potential Side Effects of SAM-e

SAM-e has been found to be safe supplement with no reported adverse side effects or contraindications. Occasionally, an animal may experience vomiting after SAM-e administration, but it is very rare occurrence. Reducing the dosage and then gradually increasing it is usually enough but if the condition prevails, you should of course seek professional advice.

SAM-e is available over-the-counter (OTC) but it should be administered under Vet supervision for pets with liver disease, kidney disease, bleeding disorder or diabetes. It should not be used in cases of bile duct obstruction. And as with most supplementation, safe use in pregnant or breeding animals has not been proven.

You may ask why a product for pets with liver problems recommends Vet supervision. This is because liver disease is a serious condition and you should always start by seeing your Vet to discuss the right course of action for your pet and have the necessary tests done prior to starting any treatment.

Where To Buy MaxxiSAMe

Click on the country flag to buy your MaxxiSAMe on Amazon NOW.

Next: The Ingredients in MaxxiSAMe